What is this medication?

FLUCONAZOLE (floo KON na zole) prevents and treats fungal or yeast infections. It belongs to a group of medications called antifungals. It will not prevent or treat colds, the flu, or infections caused by bacteria or viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Diflucan

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Irregular heartbeat or rhythm
• Kidney disease
• Liver disease
• Low levels of potassium in the blood
• An unusual or allergic reaction to fluconazole, other antifungal medications, foods, dyes or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is for injection into a vein. It is usually given in a hospital or clinic setting.

If you get this medication at home, you will be taught how to prepare and give this medication. Use exactly as directed. Take your medication at regular intervals. Do not take your medication more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

Do not take this medication with any of the following:

• Flibanserin
• Lomitapide
• Lonafarnib
• Other medications that prolong the QT interval (cause an abnormal heart rhythm)
• Triazolam

This medication may also interact with the following:

• Certain antibiotics like rifabutin, rifampin
• Certain antivirals for HIV or hepatitis
• Certain medications for blood pressure, heart disease, irregular heartbeat
• Certain medications for cholesterol like atorvastatin, lovastatin, and simvastatin
• Certain medications for depression, like amitriptyline, nortriptyline
• Certain medications for diabetes like glipizide or glyburide
• Certain medications for seizures like carbamazepine, phenytoin
• Certain medications that treat or prevent blood clots like warfarin
• Certain narcotic medications for pain like alfentanil, fentanyl, methadone
• Cyclophosphamide
• Cyclosporine
• Ibrutinib
• Lemborexant
• Midazolam
• NSAIDS, medications for pain and inflammation, like ibuprofen or naproxen
• Olaparib
• Sirolimus
• Steroid medications like prednisone
• Tacrolimus
• Theophylline
• Tofacitinib
• Tolvaptan
• Vinblastine
• Vincristine
• Vitamin A
• Voriconazole

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not improve. If you are taking this medication for a long time you may need blood work. Some fungal infections need many weeks or months of treatment to cure completely.

Alcohol can increase possible damage to your liver from this medication. Avoid alcoholic drinks.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
• Rash, fever, and swollen lymph nodes
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Seizures

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Change in taste
• Diarrhea
• Dizziness
• Headache
• Nausea
• Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

If you are using this medication at home, you will be instructed on how to store this medication. Throw away any unused medication after the expiration date on the label.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.