What is this medication?

FLUCONAZOLE (floo KON na zole) prevents and treats fungal or yeast infections. It belongs to a group of medications called antifungals. It will not prevent or treat colds, the flu, or infections caused by bacteria or viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Diflucan

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Irregular heartbeat or rhythm
• Kidney disease
• Liver disease
• Low levels of potassium in the blood
• An unusual or allergic reaction to fluconazole, other azole antifungals, medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth. Follow the directions on the prescription label. Do not take your medication more often than directed.

Talk to your care team about the use of this medication in children. Special care may be needed. This medication has been used in children as young as 6 months of age.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following medications:

• Flibanserin
• Lomitapide
• Lonafarnib
• Other medications that prolong the QT interval (cause an abnormal heart rhythm)
• Triazolam

This medication may also interact with the following medications:

• Certain antibiotics like rifabutin, rifampin
• Certain antivirals for HIV or hepatitis
• Certain medications for blood pressure, heart disease, irregular heartbeat
• Certain medications for cholesterol like atorvastatin, lovastatin, and simvastatin
• Certain medications for depression, like amitriptyline, nortriptyline
• Certain medications for diabetes like glipizide or glyburide
• Certain medications for seizures like carbamazepine, phenytoin
• Certain medications that treat or prevent blood clots like warfarin
• Certain narcotic medications for pain like alfentanil, fentanyl, methadone
• Cyclophosphamide
• Cyclosporine
• Ibrutinib
• Lemborexant
• Midazolam
• NSAIDS, medications for pain and inflammation, like ibuprofen or naproxen
• Olaparib
• Sirolimus
• Steroid medications like prednisone
• Tacrolimus
• Theophylline
• Tofacitinib
• Tolvaptan
• Vinblastine
• Vincristine
• Vitamin A
• Voriconazole

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checkups. If you are taking this medication for a long time you may need blood work. Tell your care team if your symptoms do not improve. Some fungal infections need many weeks or months of treatment to cure.

Alcohol can increase possible damage to your liver. Avoid alcoholic drinks.

If you have a vaginal infection, do not have sex until you have finished your treatment. You can wear a sanitary napkin. Do not use tampons. Wear freshly washed cotton, not synthetic, panties.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
• Rash, fever, and swollen lymph nodes
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Seizures

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Change in taste
• Diarrhea
• Dizziness
• Headache
• Nausea
• Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Throw away any medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.