What is this medication?

GRANISETRON (gra NI se tron) is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Granisol, Kytril

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•liver disease

•an unusual or allergic reaction to granisetron, ondansetron, other medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

Take this medicine by mouth. Follow the directions on your prescription label. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medicine is only given on the day(s) chemotherapy or radiation is given.

What may interact with this medication?

Do not take this medicine with any of the following medications:

• certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
• cisapride
• dronedarone
• pimozide
• thioridazine

This medicine may also interact with the following medications:

• certain medicines for depression, anxiety, or psychotic disturbances
• fentanyl
• linezolid
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
• methylene blue (injected into a vein)
• other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
• phenobarbital
• tramadol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored after taking this medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

•confusion

•difficulty breathing, wheezing, shortness of breath

•dizziness

•fast or irregular heartbeat

•feeling faint or lightheaded, falls

•fever and chills

•loss of balance or coordination

•seizures

•skin rash, itching

•sweating

•swelling of the face, tongue, throat, hands and feet

•tightness in the chest

•tremors

•unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•constipation or diarrhea

•headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (56 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.