What is this medication?

AMINOPHYLLINE (am in OFF i lin) treats asthma and chronic obstructive pulmonary disease (COPD). It works by opening the airways of the lungs, making it easier to breathe.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Heart disease
• Irregular heartbeat or rhythm
• Liver disease
• Seizures
• Stomach ulcers, other stomach or intestine problems
• Thyroid disease
• Tobacco use
• An unusual or allergic reaction to theophylline, aminophylline, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be prescribed to children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Do not take this medication with any of the following:

• Riociguat
• Viloxazine

This medication may also interact with the following:

• Allopurinol
• Aminoglutethimide
• Caffeine
• Certain antibiotics like ciprofloxacin, enoxacin, telithromycin, erythromycin or clarithromycin
• Certain medications for blood pressure, heart disease, irregular heart beat like adenosine, mexiletine, propafenone, propranolol, verapamil
• Certain medications for sleep or anxiety
• Certain medications for seizures like carbamazepine, phenobarbital, phenytoin
• Certain medications used during surgery
• Cimetidine
• Disulfiram
• Ephedrine
• Estrogens or progestin hormones
• Fluvoxamine
• Interferon alpha
• Isoproterenol
• Lithium
• Methotrexate
• Pentoxifylline
• Rifampin
• St. John's Wort
• Sulfinpyrazone
• Thiabendazole
• Ticlopidine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

You may need blood work while you are taking this medication.

If you smoke, tell your care team if you notice this medication is not working well for you. Talk to your care team if you decide to stop smoking.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Theophylline toxicity—nausea, vomiting, stomach pain, fast or irregular heartbeat, seizures

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Anxiety, nervousness
• Headache
• Nausea
• Tremors or shaking
• Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.